Press Release

PepTcell and Gador Announce Collaboration to Develop Novel Vaccine for “Neglected” Chagas disease

FOR IMMEDIATE RELEASE

Monday 17 December 2007

PepTcell and Gador Announce Collaboration to Develop
Novel Vaccine for “Neglected” Chagas disease

High Wycombe, UK and Buenos Aires, Argentina - 17th December 2007 PepTcell Ltd. and
Gador S.A. today announced an R&D collaboration to develop a novel T-cell vaccine for Chagas
disease, a neglected tropical disease with no adequate treatment or vaccination.

PepTcell will develop the T-cell vaccine, using its proprietary technology and expertise to identify
parasitic proteins capable of inducing a T-cell immune response. T-cells play a key role in
recognising and eliminating the parasite from infected human cells.

Once the vaccine is ready to enter Phase III, Gador will assume responsibility for its
development, commercialisation in Argentina and manufacturing. PepTcell will receive
undisclosed royalties based on net sales.

Stuart Robinson, Head of Business Development of PepTcell commented, “With our expertise in
T-cell vaccine development, coupled with Gador’s resources and experience of the Latin
American market, we believe this T-cell vaccine development programme could revolutionise the
management of Chagas disease. Currently, there are only two pharmaceutical treatments
available for Chagas disease, both with serious side effects, and we are very excited by the
prospect of developing an effective vaccine.”

Alberto Alvarez Saavedra, Vice president of Gador said: “As one of the leading pharmaceutical
companies in Argentina devoted to people’s health, we are committed to find solutions to Chagas
disease. The disease continues to have a detrimental effect on millions of people in Latin
America, nearly a hundred years after the condition was first discovered. Using PepTcell’s novel
approach we hope to develop an effective vaccine for Chagas disease.”

Chagas Disease is a major public health issue, affecting approximately 18 million people in Latin
America and hindering socioeconomic development in the region where 120 million are at risk of
contracting the infection. Chagas is one of the leading causes of heart failure in Latin America.
Recognised as a neglected disease, the World Health Organisation (WHO) recently set up a
global initiative to increase awareness and eradicate the disease by 2010. The need for an
effective vaccine has never been greater with increasing evidence of emerging drug resistance,
new vectors and spread to non-endemic areas such as USA, Canada and Europe.

-ENDSNOTES

FOR EDITORS

About PepTcell Ltd

PepTcell is a biotechnology company focused on applying its breakthrough technology to the
development of a new class of vaccines – T-cell vaccines – against highly mutagenic viruses. The
Company began operating in 2004; however the founding shareholders and key employees have
been working on this novel concept for over 20 years.

Since its inception, the Company has completed the majority of its pre-clinical work for its
influenza and HIV vaccines. PepTcell’s lead product Flu-v, a single treatment flu vaccine is about
to enter clinical trials in the UK. The vaccine, developed to be effective against all strains of flu
virus (technical animation available) could eliminate the need for annual flu vaccinations.

PepTCell, a private Company, headquartered in High Wycombe, UK is in the process of finalising
all the manufacturing processes for its Flu-v vaccine, and successfully raised capital from a range
of investors.

For further information please visit the website at www.peptcell.com

About Gador S.A.

Gador is an argentine private pharmaceutical company incorporated in 1940. The company has a
turnover in Argentina of over USD100 million, and sells finished products (from its own plants
approved by MERCOSUR authorities) and active principles (from its own plants approved by FDA
and EMEA authorities) in the five continents in more than 30 countries. For over fifty years, Gador
has represented licences from Astellas (former Fujisawa), Gilead, Recordati and Eli Lilly among
others. Gador is also involved in pharmaceutical distribution (under a partnership in Farmanet
S.A. with Novartis, Boehringer Ingelheim, and other argentine companies).

In the area of R&D, with a long-standing relationship and scientific collaboration with the
University of Leiden (Holland) and Argentine universities, a new molecule is under development
for bone diseases, INN: Olpadronate. The clinical assays carried out in Holland as well as in
Argentina have proved to have a high effectiveness and tolerance in the treatment of Paget bone
disease as well in other orphan diseases. Gador is one of only five companies worldwide doing
R&D in the bisphosphonates area, holding a strong portfolio of patents and IP rights.

More than 20 years ago, Gador started research in Chagas disease. As a result of these efforts,
Gador developed and produced the first commercial biotech diagnostic kit worldwide for the
detection of Chagas disease, containing a mix of recombinant antigens of Trypanosoma cruzi.

For further information please visit the website at www.gador.com

About Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical disease affecting
approximately 18 million people in Latin America where 120 million are at risk of contracting the
infection.

In most cases, humans are infected by strain Trypanosoma cruzi II, which is mainly transmitted
by Triatominae insects (a.k.a “vinchuca”, “kissing bugs”, or “assassin bugs”), blood transfusions
and organ transplantations. Therefore, it tends to mainly affect impoverished and rural
communities in the tropics - the breeding ground for the triatomine insects.

Symptoms seen after infection are mild and may include fever, swelling at the site of the insect
bite and of the lymph glands, and enlargement of the liver and spleen. This is often followed by a’
latent’ period of up to 20 years, where heart and gastrointestinal tissues are progressively
damaged without any symptoms. The burden of chronic Chagas disease is highlighted by the
fact that Chagas Disease is one of the leading cause of heart failure in Latin America.
Current pharmacological treatments leave much to be desired, with limited efficacy, serious side
effects and a hefty price tag. Latin American countries have made significant strides in controlling mortality rates through insect control initiatives, but these are usually expensive and temporary effective.

For further information please contact:

College Hill
Katja Stout, Tony Stephenson, Raji Nandipati
Tel: +44 (0)20 7457 2020
E-mail: peptcell@collegehill.com

At Gador
Dr. Valentina Carricarte
Chagas Project Leader
Tel : 54 11 4858 9000
Email : vcarricarte@gador.com.ar

At PepTcell
Gregory Stoloff
Managing Director
Tel: + 44 (0)870 351 4608
Email: gregory.stoloff@peptcell.com

Dr Stuart Robinson
Head of Business Development
Tel: +44 (0) 870 734 6520
Email: stuart.robinson@peptcell.com

Dr Wilson Caparros-Wanderley
Chief Scientific Officer
Tel: +44 (0) 870 351 4614
Email: wilson.wanderley@peptcell.com

 
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